Propionibacterium acnes: An Underestimated Pathogen in Implant-Associated Infections.

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Version: author
Serval ID
serval:BIB_3364E85DEFA7
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Propionibacterium acnes: An Underestimated Pathogen in Implant-Associated Infections.
Journal
Biomed Research International
Author(s)
Portillo M.E., Corvec S., Borens O., Trampuz A.
ISSN
2314-6141 (Electronic)
Publication state
Published
Issued date
2013
Volume
2013
Pages
804391
Language
english
Notes
Publication types: REVIEWPublication Status: ppublishDocument Type: Review
Abstract
The role of Propionibacterium acnes in acne and in a wide range of inflammatory diseases is well established. However, P. acnes is also responsible for infections involving implants. Prolonged aerobic and anaerobic agar cultures for 14 days and broth cultures increase the detection rate. In this paper, we review the pathogenic role of P. acnes in implant-associated infections such as prosthetic joints, cardiac devices, breast implants, intraocular lenses, neurosurgical devices, and spine implants. The management of severe infections caused by P. acnes involves a combination of antimicrobial and surgical treatment (often removal of the device). Intravenous penicillin G and ceftriaxone are the first choice for serious infections, with vancomycin and daptomycin as alternatives, and amoxicillin, rifampicin, clindamycin, tetracycline, and levofloxacin for oral treatment. Sonication of explanted prosthetic material improves the diagnosis of implant-associated infections. Molecular methods may further increase the sensitivity of P. acnes detection. Coating of implants with antimicrobial substances could avoid or limit colonization of the surface and thereby reduce the risk of biofilm formation during severe infections. Our understanding of the role of P. acnes in human diseases will likely continue to increase as new associations and pathogenic mechanisms are discovered.
Pubmed
Web of science
Open Access
Yes
Create date
07/12/2013 17:02
Last modification date
20/08/2019 13:19
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