CDK4, a new metabolic sensor that antagonizes AMPK.

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State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_31B3469F93CE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
UNIL/CHUV
Title
CDK4, a new metabolic sensor that antagonizes AMPK.
Journal
Molecular & cellular oncology
Author(s)
Fajas L., Lopez-Mejia I.C.
ISSN
2372-3556 (Print)
ISSN-L
2372-3556
Publication state
Published
Issued date
2018
Peer-reviewed
Oui
Volume
5
Number
5
Pages
e1409862
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Cyclin-dependent kinase 4 (CDK4) is a positive regulator of cell cycle progression, however, there is growing evidence demonstrating that its function exceeds the control of cell division. Here we show that CDK4 is an important regulator of cellular substrate utilization through direct inhibition of the metabolic regulator AMPK (AMP-activated protein kinase).
Keywords
AMPK, CDK4, Cell Cycle, Fatty acid oxidation, Metabolism, Tumor metabolism
URN
urn:nbn:ch:serval-BIB_31B3469F93CE4
OAI-PMH
oai:serval.unil.ch:BIB_31B3469F93CE
DOI
10.1080/23723556.2017.1409862
Pubmed
30263936
Web of science
000445439200007
Open Access
Yes
Create date
04/11/2018 17:20
Last modification date
21/08/2019 7:08
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