Prognostic factors in solitary plasmacytoma of the bone: a multicenter Rare Cancer Network study.

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Serval ID
serval:BIB_2D5473DF94BF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Prognostic factors in solitary plasmacytoma of the bone: a multicenter Rare Cancer Network study.
Journal
BMC Cancer
Author(s)
Knobel D., Zouhair A., Tsang R.W., Poortmans P., Belkacémi Y., Bolla M., Oner F.D., Landmann C., Castelain B., Ozsahin M.
ISSN
1471-2407
Publication state
Published
Issued date
2006
Peer-reviewed
Oui
Volume
6
Pages
118
Language
english
Notes
Publication types: Journal Article ; Multicenter Study
Abstract
BACKGROUND: Solitary plasmacytoma (SP) of the bone is a rare plasma-cell neoplasm. There are no conclusive data in the literature on the optimal radiation therapy (RT) dose in SP. Therefore, in this large retrospective study, we wanted to assess the outcome, prognostic factors, and the optimal RT dose in patients with SP. METHODS: Data from 206 patients with bone SP without evidence of multiple myeloma (MM) were collected. Histopathological diagnosis was obtained for all patients. The majority (n = 169) of the patients received RT alone; 32 chemotherapy and RT, and 5 surgery. Median follow-up was 54 months (7-245). RESULTS: Five-year overall survival, disease-free survival (DFS), and local control was 70%, 46%, and 88%; respectively. Median time to MM development was 21 months (2-135) with a 5-year probability of 51%. In multivariate analyses, favorable factors were younger age and tumor size < 5 cm for survival; younger age for DFS; anatomic localization (vertebra vs. other) for local control. Older age was the only predictor for MM. There was no dose-response relationship for doses 30 Gy or higher, even for larger tumors. CONCLUSION: Younger patients, especially those with vertebral localization have the best outcome when treated with moderate-dose RT. Progression to MM remains the main problem. Further investigation should focus on adjuvant chemotherapy and/or novel therapeutic agents.
Keywords
Actuarial Analysis, Adult, Age Factors, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols, Bone Neoplasms, Chemotherapy, Adjuvant, Cohort Studies, Combined Modality Therapy, Dexamethasone, Disease Progression, Disease-Free Survival, Dose-Response Relationship, Radiation, Doxorubicin, Europe, Female, Follow-Up Studies, Humans, Male, Melphalan, Middle Aged, Multiple Myeloma, North America, Plasmacytoma, Prednisone, Prognosis, Proportional Hazards Models, Radiotherapy Dosage, Retrospective Studies, Spinal Neoplasms, Treatment Outcome, Vincristine
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 17:20
Last modification date
20/08/2019 13:12
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