Variants in MTNR1B influence fasting glucose levels.

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Version: Author's accepted manuscript
Serval ID
serval:BIB_2AFD50467B1C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Variants in MTNR1B influence fasting glucose levels.
Journal
Nature Genetics
Author(s)
Prokopenko I., Langenberg C., Florez J.C., Saxena R., Soranzo N., Thorleifsson G., Loos R.J., Manning A.K., Jackson A.U., Aulchenko Y., Potter S.C., Erdos M.R., Sanna S., Hottenga J.J., Wheeler E., Kaakinen M., Lyssenko V., Chen W.M., Ahmadi K., Beckmann J.S., Bergman R.N., Bochud M., Bonnycastle L.L., Buchanan T.A., Cao A., Cervino A., Coin L., Collins F.S., Crisponi L., de Geus E.J., Dehghan A., Deloukas P., Doney A.S., Elliott P., Freimer N., Gateva V., Herder C., Hofman A., Hughes T.E., Hunt S., Illig T., Inouye M., Isomaa B., Johnson T., Kong A., Krestyaninova M., Kuusisto J., Laakso M., Lim N., Lindblad U., Lindgren C.M., McCann O.T., Mohlke K.L., Morris A.D., Naitza S., Orrù M., Palmer C.N., Pouta A., Randall J., Rathmann W., Saramies J., Scheet P., Scott L.J., Scuteri A., Sharp S., Sijbrands E., Smit J.H., Song K., Steinthorsdottir V., Stringham H.M., Tuomi T., Tuomilehto J., Uitterlinden A.G., Voight B.F., Waterworth D., Wichmann H.E., Willemsen G., Witteman J.C., Yuan X., Zhao J.H., Zeggini E., Schlessinger D., Sandhu M., Boomsma D.I., Uda M., Spector T.D., Penninx B.W., Altshuler D., Vollenweider P., Jarvelin M.R., Lakatta E., Waeber G., Fox C.S., Peltonen L., Groop L.C., Mooser V., Cupples L.A., Thorsteinsdottir U., Boehnke M., Barroso I., Van Duijn C., Dupuis J., Watanabe R.M., Stefansson K., McCarthy M.I., Wareham N.J., Meigs J.B., Abecasis G.R.
ISSN
1546-1718
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
41
Number
1
Pages
77-81
Language
english
Abstract
To identify previously unknown genetic loci associated with fasting glucose concentrations, we examined the leading association signals in ten genome-wide association scans involving a total of 36,610 individuals of European descent. Variants in the gene encoding melatonin receptor 1B (MTNR1B) were consistently associated with fasting glucose across all ten studies. The strongest signal was observed at rs10830963, where each G allele (frequency 0.30 in HapMap CEU) was associated with an increase of 0.07 (95% CI = 0.06-0.08) mmol/l in fasting glucose levels (P = 3.2 x 10(-50)) and reduced beta-cell function as measured by homeostasis model assessment (HOMA-B, P = 1.1 x 10(-15)). The same allele was associated with an increased risk of type 2 diabetes (odds ratio = 1.09 (1.05-1.12), per G allele P = 3.3 x 10(-7)) in a meta-analysis of 13 case-control studies totaling 18,236 cases and 64,453 controls. Our analyses also confirm previous associations of fasting glucose with variants at the G6PC2 (rs560887, P = 1.1 x 10(-57)) and GCK (rs4607517, P = 1.0 x 10(-25)) loci.
Keywords
Blood Glucose, Case-Control Studies, Diabetes Mellitus, Type 2, Fasting, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Meta-Analysis as Topic, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Receptor, Melatonin, MT2, Receptors, Melatonin, Colaus Study
Pubmed
Web of science
Create date
20/02/2009 13:21
Last modification date
20/08/2019 13:10
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