Programming Hippocampal Neural Stem/Progenitor Cells into Oligodendrocytes Enhances Remyelination in the Adult Brain after Injury.

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Version: Final published version
Serval ID
serval:BIB_2A455A26C366
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Programming Hippocampal Neural Stem/Progenitor Cells into Oligodendrocytes Enhances Remyelination in the Adult Brain after Injury.
Journal
Cell Reports
Author(s)
Braun S.M., Pilz G.A., Machado R.A., Moss J., Becher B., Toni N., Jessberger S.
ISSN
2211-1247 (Electronic)
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
11
Number
11
Pages
1679-1685
Language
english
Abstract
Demyelinating diseases are characterized by a loss of oligodendrocytes leading to axonal degeneration and impaired brain function. Current strategies used for the treatment of demyelinating disease such as multiple sclerosis largely rely on modulation of the immune system. Only limited treatment options are available for treating the later stages of the disease, and these treatments require regenerative therapies to ameliorate the consequences of oligodendrocyte loss and axonal impairment. Directed differentiation of adult hippocampal neural stem/progenitor cells (NSPCs) into oligodendrocytes may represent an endogenous source of glial cells for cell-replacement strategies aiming to treat demyelinating disease. Here, we show that Ascl1-mediated conversion of hippocampal NSPCs into mature oligodendrocytes enhances remyelination in a diphtheria-toxin (DT)-inducible, genetic model for demyelination. These findings highlight the potential of targeting hippocampal NSPCs for the treatment of demyelinated lesions in the adult brain.
Pubmed
Web of science
Open Access
Yes
Create date
29/07/2015 10:13
Last modification date
20/08/2019 13:09
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