A quorum sensing small volatile molecule promotes antibiotic tolerance in bacteria.

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Serval ID
serval:BIB_223B7CEDC463
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A quorum sensing small volatile molecule promotes antibiotic tolerance in bacteria.
Journal
PLoS One
Author(s)
Que Y.A., Hazan R., Strobel B., Maura D., He J., Kesarwani M., Panopoulos P., Tsurumi A., Giddey M., Wilhelmy J., Mindrinos M.N., Rahme L.G.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
8
Number
12
Pages
e80140
Language
english
Abstract
Bacteria can be refractory to antibiotics due to a sub-population of dormant cells, called persisters that are highly tolerant to antibiotic exposure. The low frequency and transience of the antibiotic tolerant "persister" trait has complicated elucidation of the mechanism that controls antibiotic tolerance. In this study, we show that 2' Amino-acetophenone (2-AA), a poorly studied but diagnostically important small, volatile molecule produced by the recalcitrant gram-negative human pathogen Pseudomonas aeruginosa, promotes antibiotic tolerance in response to quorum-sensing (QS) signaling. Our results show that 2-AA mediated persister cell accumulation occurs via alteration of the expression of genes involved in the translational capacity of the cell, including almost all ribosomal protein genes and other translation-related factors. That 2-AA promotes persisters formation also in other emerging multi-drug resistant pathogens, including the non 2-AA producer Acinetobacter baumannii implies that 2-AA may play an important role in the ability of gram-negative bacteria to tolerate antibiotic treatments in polymicrobial infections. Given that the synthesis, excretion and uptake of QS small molecules is a common hallmark of prokaryotes, together with the fact that the translational machinery is highly conserved, we posit that modulation of the translational capacity of the cell via QS molecules, may be a general, widely distributed mechanism that promotes antibiotic tolerance among prokaryotes.
Pubmed
Web of science
Open Access
Yes
Create date
08/01/2014 16:28
Last modification date
20/08/2019 12:59
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