Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites: Two randomized, controlled, crossover intervention trials.

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Version: Final published version
Serval ID
serval:BIB_20C4095737A4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites: Two randomized, controlled, crossover intervention trials.
Journal
Clinical nutrition
Author(s)
Mills C.E., Flury A., Marmet C., Poquet L., Rimoldi S.F., Sartori C., Rexhaj E., Brenner R., Allemann Y., Zimmermann D., Gibson G.R., Mottram D.S., Oruna-Concha M.J., Actis-Goretta L., Spencer JPE
ISSN
1532-1983 (Electronic)
ISSN-L
0261-5614
Publication state
Published
Issued date
12/2017
Peer-reviewed
Oui
Volume
36
Number
6
Pages
1520-1529
Language
english
Notes
Publication types: Journal Article ; Randomized Controlled Trial
Publication Status: ppublish
Abstract
Polyphenol intake has been linked to improvements in human vascular function, although data on hydroxycinnamates, such as chlorogenic acid (CGA) have not yet been studied. We aimed to investigate the impact of coffee intake rich in chlorogenic acid on human vascular function and whether CGAs are involved in potential effects.
Two acute randomized, controlled, cross-over human intervention trials were conducted. The impact of coffee intake, matched for caffeine but differing in CGA content (89, and 310 mg) on flow-mediated dilatation (FMD) was assessed in 15 healthy male subjects. In a second intervention trial conducted with 24 healthy male subjects, the impact of pure 5-caffeoylquinic acid (5-CQA), the main CGA in coffee (5-CQA; 450 mg and 900 mg) on FMD was also investigated.
We observed a bi-phasic FMD response after low and high polyphenol, (89 mg and 310 mg CGA) intake, with increases at 1 (1.10 ± 0.43% and 1.34 ± 0.62%, respectively) and 5 (0.79% ± 0.32 and 1.52% ± 0.40, respectively) hours post coffee consumption. FMD responses to coffee intake was closely paralleled by the appearance of CGA metabolites in plasma, notably 3-, 4- and 5-feruloylquinic acid and ferulic-4'-O-sulfate at 1 h and isoferulic-3'-O-glucuronide and ferulic-4'-O-sulfate at 5 h. Intervention with purified 5-CQA (450 mg) also led to an improvement in FMD response relative to control (0.75 ± 1.31% at 1 h post intervention, p = 0.06) and concomitant appearance of plasma metabolites.
Coffee intake acutely improves human vascular function, an effect, in part, mediated by 5-CQA and its physiological metabolites.
The National Institutes of Health (NIH) on ClinicalTrials.govNCT01813981 and NCT01772784.
Keywords
Adolescent, Adult, Aged, Blood Pressure/drug effects, Body Mass Index, Chlorogenic Acid/administration & dosage, Chlorogenic Acid/blood, Coffee, Cross-Over Studies, Endothelium, Vascular/drug effects, Humans, Male, Middle Aged, Polyphenols/administration & dosage, Polyphenols/blood, Quinic Acid/administration & dosage, Quinic Acid/analogs & derivatives, Quinic Acid/blood, Single-Blind Method, Young Adult, Chlorogenic acid, Flow mediated dilatation (FMD), Phenolics, Vascular
Pubmed
Web of science
Open Access
Yes
Create date
03/01/2017 19:16
Last modification date
20/08/2019 12:57
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