Do glial cells control pain?

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Serval ID
serval:BIB_1CE1CA6609D7
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Do glial cells control pain?
Journal
Neuron Glia Biology
Author(s)
Suter M.R., Wen Y.R., Decosterd I., Ji R.R.
ISSN
1741-0533 (Electronic)
ISSN-L
1740-925X
Publication state
Published
Issued date
2007
Volume
3
Number
3
Pages
255-268
Language
english
Abstract
Management of chronic pain is a real challenge, and current treatments focusing on blocking neurotransmission in the pain pathway have only resulted in limited success. Activation of glia cells has been widely implicated in neuroinflammation in the central nervous system, leading to neruodegeneration in many disease conditions such as Alzheimer's and multiple sclerosis. The inflammatory mediators released by activated glial cells, such as tumor necrosis factor-α and interleukin-1β can not only cause neurodegeneration in these disease conditions, but also cause abnormal pain by acting on spinal cord dorsal horn neurons in injury conditions. Pain can also be potentiated by growth factors such as BDNF and bFGF that are produced by glia to protect neurons. Thus, glia cells can powerfully control pain when they are activated to produce various pain mediators. We will review accumulating evidence supporting an important role of microglia cells in the spinal cord for pain control under injury conditions (e.g. nerve injury). We will also discuss possible signaling mechanisms in particular MAP kinase pathways that are critical for glia control of pain. Investigating signaling mechanisms in microglia may lead to more effective management of devastating chronic pain.
Pubmed
Web of science
Create date
08/09/2011 20:38
Last modification date
20/08/2019 12:53
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