Synapse formation on adult-born hippocampal neurons.

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State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_0B610E672E80
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Synapse formation on adult-born hippocampal neurons.
Journal
European Journal of Neuroscience
Author(s)
Toni N., Sultan S.
ISSN
1460-9568 (Electronic)
ISSN-L
0953-816X
Publication state
Published
Issued date
2011
Volume
33
Number
6
Pages
1062-1068
Language
english
Abstract
It is now widely accepted that adult neurogenesis plays a fundamental role in hippocampal function. Neurons born in the adult dentate gyrus of the hippocampus undergo a series of events before they fully integrate in the network and eventually become undistinguishable from neurons born during embryogenesis. Adult hippocampal neurogenesis is strongly regulated by neuronal activity and neurotransmitters, and the synaptic integration of adult-born neurons occurs in discrete steps, some of which are very different from perinatal synaptogenesis. Here, we review the current knowledge on the development of the synaptic input and output of neurons born in the adult hippocampus, from the stem/progenitor cell to the fully mature neuron. We also provide insight on the regulation of adult neurogenesis by some neurotransmitters and discuss some specificities of the integration of new neurons in an adult environment. The understanding of the mechanisms regulating the synaptic integration of adult-born neurons is not only crucial for our understanding of brain plasticity, but also provides a framework for the manipulation and monitoring of endogenous adult neurogenesis as well as grafted cells, for potential therapeutic applications.
Keywords
dentate gyrus, neurogenesis, plasticity, stem cells, synaptogenesis
Pubmed
Web of science
Create date
07/04/2011 8:52
Last modification date
20/08/2019 12:33
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