Pathfinding of corticothalamic axons relies on a rendezvous with thalamic projections.

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Serval ID
serval:BIB_026EA9F84549
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Pathfinding of corticothalamic axons relies on a rendezvous with thalamic projections.
Journal
Neuron
Author(s)
Deck M., Lokmane L., Chauvet S., Mailhes C., Keita M., Niquille M., Yoshida M., Yoshida Y., Lebrand C., Mann F., Grove E.A., Garel S.
ISSN
1097-4199 (Electronic)
ISSN-L
0896-6273
Publication state
Published
Issued date
2013
Volume
77
Number
3
Pages
472-484
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
Major outputs of the neocortex are conveyed by corticothalamic axons (CTAs), which form reciprocal connections with thalamocortical axons, and corticosubcerebral axons (CSAs) headed to more caudal parts of the nervous system. Previous findings establish that transcriptional programs define cortical neuron identity and suggest that CTAs and thalamic axons may guide each other, but the mechanisms governing CTA versus CSA pathfinding remain elusive. Here, we show that thalamocortical axons are required to guide pioneer CTAs away from a default CSA-like trajectory. This process relies on a hold in the progression of cortical axons, or waiting period, during which thalamic projections navigate toward cortical axons. At the molecular level, Sema3E/PlexinD1 signaling in pioneer cortical neurons mediates a "waiting signal" required to orchestrate the mandatory meeting with reciprocal thalamic axons. Our study reveals that temporal control of axonal progression contributes to spatial pathfinding of cortical projections and opens perspectives on brain wiring.
Keywords
Age Factors, Animals, Axons/physiology, Body Patterning/genetics, Calcium-Binding Protein, Vitamin D-Dependent/metabolism, Cerebral Cortex/cytology, Cerebral Cortex/physiology, Contactin 2/metabolism, DNA-Binding Proteins/metabolism, Embryo, Mammalian, Gene Expression Regulation, Developmental/genetics, Glycoproteins/genetics, Homeodomain Proteins/genetics, Leukocyte L1 Antigen Complex/metabolism, Luminescent Proteins/genetics, Luminescent Proteins/metabolism, Membrane Glycoproteins/genetics, Membrane Proteins/genetics, Mice, Mice, Inbred C57BL, Mice, Transgenic, Nerve Tissue Proteins/genetics, Nerve Tissue Proteins/metabolism, Neural Pathways/physiology, Nuclear Proteins/metabolism, POU Domain Factors/genetics, Repressor Proteins/metabolism, Thalamus/cytology, Thalamus/physiology, Transcription Factors/genetics, Transcription Factors/metabolism, Tumor Suppressor Proteins/metabolism, Wnt3A Protein/genetics, tau Proteins/genetics
Pubmed
Web of science
Open Access
Yes
Create date
03/05/2013 19:52
Last modification date
20/08/2019 12:24
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