Swiss clinical practice guidelines for skin cancer in organ transplant recipients.

Details

Ressource 1Download: 19680830.pdf (120.26 [Ko])
State: Public
Version: Final published version
Serval ID
serval:BIB_00C4BE73949B
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Swiss clinical practice guidelines for skin cancer in organ transplant recipients.
Journal
Swiss medical weekly
Author(s)
Hofbauer G.F., Anliker M., Arnold A., Binet I., Hunger R., Kempf W., Laffitte E., Lapointe A.C., Pascual M., Pelloni F., Serra A.
Working group(s)
SGDV working group for organ transplant recipients
ISSN
1424-7860 (Print)
ISSN-L
0036-7672
Publication state
Published
Issued date
25/07/2009
Peer-reviewed
Oui
Volume
139
Number
29-30
Pages
407-415
Language
english
Notes
Publication types: Journal Article ; Practice Guideline
Publication Status: ppublish
Abstract
Patients with a solid organ transplant have increased in numbers and in individual survival in Switzerland over the last decades. As a consequence of long-term immunosuppression, skin cancer in solid organ recipients (SOTRs) has been recognized as an important problem. Screening and education of potential SOTRs about prevention of sun damage and early recognition of skin cancer are important before transplantation. Once transplanted, SOTRs should be seen by a dermatologist yearly for repeat education as well as early diagnosis, prevention and treatment of skin cancer. Squamous cell carcinoma of the skin (SCC) is the most frequent cancer in the setting of long-term immunosuppression. Sun protection by behaviour, clothing and daily sun screen application is the most effective prevention. Cumulative sun damage results in field cancerisation with numerous in-situ SCC such as actinic keratosis and Bowen's disease which should be treated proactively. Invasive SCC is cured by complete surgical excision. Early removal is the best precaution against potential metastases of SCC. Reduction of immunosuppression and switch to mTOR inhibitors and potentially, mycophenolate, may reduce the incidence of further SCC. Chemoprevention with the retinoid acitretin reduces the recurrence rate of SCC. The dermatological follow-up of SOTRs should be integrated into the comprehensive post-transplant care.

Keywords
Acitretin/therapeutic use, Anticarcinogenic Agents/therapeutic use, Carcinoma, Squamous Cell/immunology, Carcinoma, Squamous Cell/prevention & control, Humans, Immunocompromised Host, Organ Transplantation/adverse effects, Skin Neoplasms/immunology, Skin Neoplasms/prevention & control, Sunscreening Agents/therapeutic use
Pubmed
Web of science
Create date
09/02/2010 11:51
Last modification date
20/08/2019 12:23
Usage data